Key publications




D. Han, Y. Park, H. Kim, J. B. Lee, Self-assembly of Free-standing RNA Membranes,

 Nature communications, 5 (2014)



Selected publications




 Sangwoo Han, Hyejin Kim, Jong Bum Lee*

Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription

 Scientific Reports, 7, 10005 (2017)  >> URL






 Impact Factor


  Jae Sung Lee, Hyejin Kim, Changshin Jo, Jaepil Jeong, Jeonghyun Ko, Sangwoo Han,   

  Min Sun Lee, Ho-Young Lee, Jeong Woo Han, Jinwoo Lee and Jong Bum Lee, Enzyme-

  driven Hasselback-like DNA-based Inorganic Superstructures (†co-first author)

  Advanced Functional Materials , Accepted (2017) 



  Sangwoo Han, Hyejin Kim, Jong Bum Lee, Library siRNA-generating RNA nanosponges

  for gene silencing by complementary rolling circle transcription

  Scientific Reports, 7, 10005 (2017)


  Sangwoo Han, Jae Sung Lee, Jong Bum Lee, Synthesis of multi-functional DNA nanosphere

  barcode system for direct cell detection

  Nanoscale, Accepted (2017)



  Joseph Long, Hyejin Kim, Dajeong Kim, Jong Bum Lee*, Deok-Ho Kim*, A biomaterials 

  approach to cell reprogramming and differentiation (* co corresponding author)

  Journal of Materials Chemistry B, 5, 2375-2389 (2017)


  Hyejin Kim, Jaepil Jeong, Dajeong Kim, Gijung Kwak, Sun Hwa Kim*, Jong Bum Lee*, 

  Bubbled RNA-based cargo for boosting RNA interference (* co corresponding author)

  Advanced Science, 4(8), 1600523 (2017)


  Jong Seong Ha, Jaesung Lee, Jaepil Jeong, Hyejin Kim, Juyoung Byun, Sang Ah Kim, 

  Hee Jae Lee, Hak Suk Chung, Jong Bum Lee, Dae-Ro Ahn, Poly-sgRNA/siRNA ribonu-

  cleoprotein nanoparticles for targeted gene disruption († co first author)

  Journal of Controlled Release, 250, 27-35 (2017)


  Jieun Kim, Dajeong Kim, Jong Bum Lee, DNA aptamer-based carrier for loading proteins

  and enhancing the enzymatic activity

  RSC Advances, 71643-1645 (2017)





 Impact Factor


  Hyejin Kim, Jae Sung Lee, Jong Bum Lee, Generation of siRNA nanosheets for efficient

  RNA interference

  Scientific Reports, 6, 25146 (2016)



  Jieun KimJong Bum Lee, Giant catalytic DNA particles for simple and intuitive detection

  of Pb2+

  Nanoscale Research Letters, 11, 244 (2016)



  Jaepil Jeong, Hyejin Kim, Dong Jun Lee, Byung Jun Jung, Jong Bum Lee, RCA-based bio-

  sensor for electrical and colorimetric detection of pathogen DNA

  Nanoscale Research Letters, 11, 242 (2016)



  Yongkuk Park, Hyejin Kim, Jong Bum Lee, Self-assembled DNA-guided RNA nanovector

  via Step-wise Dual Enzyme Polymerization (SDEP) for carrier-free siRNA delivery

  ACS Biomaterials Science & Engineering, 2(4),616–624 (2016)



  Hyejin Kim, Jong Bum Lee, Formation of RNA beads from various DNA nanoring structures

  Journal of Nanoscience Nanotechnology, 16(5), 4464-4468 (2016)



  Hyejin Kim, Yongkuk Park, Jieun Kim, Jaepil Jeong, Sangwoo Han, Jae Sung Lee, Jong 

  Bum Lee, Nucleic acid engineering: RNA following the trail of DNA

  ACS Combinatorial Science, 18(2), 87-99 (2016)






 Impact Factor


  Eun Hye Jeong, Hyejin Kim, Bora Jang, Hyesoo Cho, Jaehee Ryu, Boyeon Kim, Yonkuk

  Park, Jieun Kim, Jong Bum Lee*, Hyukjin Lee*, Technological development of structu-

  ral DNA/RNA-based RNAi systems and their applications (*co corresponding author)

  Advanced Drug Delivery Reviews, 104, 29-43 (2015)



  Hyejin Kim, Yonkuk Park, Jong Bum Lee, Self-assembled messenger RNA Nanoparticles

  (mRNA-NPs) for efficient gene expression

  Scientific Reports, 5, 12737 (2015)



  Jaepil Jeong, Hyejin Kim, Jong Bum Lee, Enzymatic polymerization on DNA modified

  gold nanowire for label-free detection of pathogen DNA

  International Journal of Molecular Sciences, 16(6), 13653-13660 (2015)



  Jieun Kim, Jae Sung Lee, Jong Bum Lee, Investigation of Förster Resonance Energy Trans-

  fer (FRET) and competition of fluorescent dyes on DNA microparticles

  International Journal of Molecular Sciences, 16(4), 7738-7747 (2015)






 Impact Factor


  Hyangsu Nam, Hyejin Kim, Yonghun Park,Jong Hwan Sung, Bumsang Kim, Hyun Cheol

  Kim, Ju Woong Jang Jong Bum lee, Fabrication of DNA-coated microneedles for trans-

  dermal DNA delivery

  Science of Advanced Materials, 6(11), 2536-2539 (2014)



  Young Hoon Roh, Jong Bum Lee, Kevin E. Shopsowitz, Erik C. Dreaden, Stephen W. 

  Morton, Zhiyong Poon, Jinkee Hong, Inbar Yamin, Daniel K. Bonner, Paula T. Hammond, 

  Layer-by-Layer assembled antisense DNA microsponge particles for efficient delivery of 

  cancer therapeutics ( co-first author)

  ACS Nano, 8(10), 9767-9780 (2014)



  Daehoon Han, Yongkuk Park, Hyangsu Nam, Jong Bum Lee, Enzymatic size control of 

  RNA particles with complementary Rolling Circle Transcription (cRCT) for efficient si-

  RNA production

  Chemical Communications, 50, 11665-11667 (2014)



  Daehoon Han, Yongkuk Park, Hyejin Kim, Jong Bum Lee, Self-assembly of free-standing 

  RNA membranes

  Nature Communications, 5, 4367 (2014)



  Younghyun Cho, Jong Bum Lee, Jinkee Hong, Controlled release of an anti-cancer drug 

  from DNA structured nano-films

  Scientific Reports, 4, (2014)






 Impact Factor


  Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee, Multi-

  plexing enhancement for the detection of multiple pathogen DNA

  Journal Nanoscience Nanotechnology, 13(11), 7295-7299 (2013)



  Jong Bum Lee, Jong Hwan Sung, Organ-on-a-chip technology and microfluidic whole-

  body models for pharmacokinetic drug toxicity screening

  Biotechnology Journal, 8(11), 1258-1266 (2013)



  Si Hyeon Kim, Jung Woo Lee, Inwook Choi, Young-Chan Kim, Jong Bum Lee, Jong 

  Hwan Sung, A microfluidic device with 3-D hydrogel villi scaffold to simulate intestinal


  Journal of Nanoscience Nanotechnology, 13(11), 7220-7228 (2013)



  Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee, Aptamer-

  based microspheres for highly sensitive protein detection using fluorescently-labeled DNA 


  Journal of Nanoscience Nanotechnology, 13(11), 7259-7263 (2013)



  Jong Bum Lee, Kim. Hyuncheol, Control of nanoparticles on branched DNA nanostructures

  Journal of Biomedical Nanotechnology, 9(7), 1245-1249 (2013)



  Jong Bum Lee, Kim. Hyuncheol, Stability of DNA nanostructures by junction penalty 

  Journal of Biomedical Nanotechnology, 9(4), 644-648 (2013)



  Younghyun Cho, Jong Bum LeeJinkee Hong, Tunable growth factor release from nano-

  assembled starch multilayers

  Chemical Engineering Journal, 221, 32-36 (2013)



  Jong Hwan sung, Daehoon Han, Jong Bum Lee, Self-assembled DNA-based giant thrombin 

  nanoparticles for controlled release

  Biotechnology Journal, 8(2), 215-220 (2013)






 Impact Factor


  Jong Bum lee, Songming Peng, Dayong Yang, Young Hoon Roh, Hisakage Funabashi, Nok-

  young Park, Edward J. Rice, Liwei Chen, Rong Long, Mingming Wu, Dan Luo, A mechani-

  cal metamaterial made from a DNA hydrogel

  Nature Nanotechnology, 7, 816-820 (2012)



  Daehoon Han, Jong Bum Lee, 핵산 나노기술 (Nucleic Acid Nonotechnology)의 의학

  적 응용

  News & Information for Chemical Engineers, 30(5), 539-546 (2012)



  Jong Bum Lee, Jinkee Hong, Daniel K. Bonner, Zhiyong Poon, paula T. Hammond, Self-

  assembled RNA interference microsponges for efficient siRNA delivery

  Nature Materials, 11, 316-322 (2012)



  Subhasish Chatterjee, Jong Bum Lee, Nikesh V. Valappil, Dan Luo, Vinod M. Menon, Prob-

  ing Y-shaped DNA structure with time-resolved FRET

  Nanoscale, 4, 1568-1571 (2012)



  Jinkee Hong, Nisarg J. Shah, Adam C. Drake, Peter C. DeMuth, Jong Bum Lee, Jianzhu

  Chen, Paula T. Hammond, Graphene multilayers as gates for multi-week sequential release 

  of proteins from surfaces

  ACS Nano, 6, 81-88 (2011)




Previous Research (~2011)


 Impact Factor


  Young Hoon Roh, Roanna C. H. Ruiz, Songming Peng, Jong Bum Lee, Dan Luo, Engi-

  neering DNA-based functional materials

  Chemical Society Reviews, 40, 5730-5744 (2011) 



  Zhiyong Poon, Jong Bum Lee, Stephen W. Morton, Paula T. Hammond, Controlling in 

  vivo stability and biodistribution in electrostatically assembled nanoparticles for systemic 


  Nano Letters, 11(5), 2096-2103 (2011)



  Young Hoon Roh, Jong Bum Lee, Pichamon Kiatwuthinon, Mark R. Hartman, Judy J. 

  Cha, Soong Ho Um, David A. Muller, Dan Luo, DNAsomes : Multifunctional DNA-

  based nanocarriers

  Small, 7, 74-78 (2011)



  Jong Bum Lee, Adam S. Shai, Michael J. Campolongo, Nokyoung Park, Dan Luo, Three-

  dimentional structure and thermal stability studies of DNA nanostructures by energy

  transfer spectroscopy

  ChemPhysChem, 11(10), 2081-2084 (2010)



  Young Hoon Roh, Jong Bum Lee, Shawn J. Tan, Bojeong Kim, Hyeongsu Park, Edward J. 

  Rice, Dan Luo, Photocrosslinked DNA nanospheres for drug delivery

  Macromolecular Rapid Communications, 31(13), 1207-1211 (2010)



  Jong Bum Lee, Michael John Campolongo, Jason Samuel Kahn, Young Hoon Roh, Mark 

  Richard Hartman, Dan Luo, DNA-based nanostructures for molecular sensing

  Nanoscale, 2, 188-197 (2010)



  Jong B. Lee, Young H. Roh, Soong Ho Um, Hisakage Funabashi, Wenlong Cheng, Judy J.

  Cha, Pichamon Kiatwuthinon, David A. Muller, Dan Luo, Multifunctional nanoarchitectures

  from DNA-based ABC monomers

  Nature Nanotechnology, 4, 430-436 (2009)



  Dwaipayan Sil, Jong Bum Lee, Dan Luo, David Holowka, Barbara Baird, Trivalent ligands 

  with rigid DNA spacers reveal structural requirements for IgE recepter signaling in RBL

  mast cells

  ACS Chemical Biology, 2, 674-684 (2007)



  Soong Ho Um, Jong Bum Lee, Nokyoung Park, Sang Yeon Kwon, Christopher C. Umbach, 

  Dan Luo, Enzyme-catalysed assembly of DNA hydrogel

  Nature Materials, 5, 797-801 (2006)



  Soong Ho Um, Jong Bum Lee, Sang Yeon Kwon, Yougen Li, Dan Luo, Dendrimer-like

  DNA-based fluorescence nanobarcodes

  Nature Protocols, 1, 995-1000 (2006)