Biomolecular NAno-intelligence Lab
Biomolecular NAno-intelligence Lab
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The Biomolecular Nano-intelligence (BNA) Lab at the University of Seoul develops nucleic-acid–based biomaterials and “biocompatible metamaterials” for applications across biosensing and drug/gene delivery. Leveraging the programmability and binding specificity of DNA/RNA, the group engineers materials that interface cleanly with cells and tissues, aiming for precise control of biological function. The lab is based in the UOS Innovation Complex in Seoul and is led by Prof. Jong Bum Lee.
Principal Investigator
Principal Investigator
Prof. Jong Bum Lee received his Ph.D. in Biological & Environmental Engineering from Cornell University (2007; thesis on DNA-templated functional materials under Prof. Dan Luo), followed by postdoctoral training at Cornell and MIT (with Prof. Paula Hammond). He directs the BNA Lab at the University of Seoul, focusing on nucleic-acid–engineered systems for delivery, sensing, and functional biomaterials
Our research
Our research
BNA’s work clusters into three pillars:
(1) Drug delivery, where nucleic-acid architectures (e.g., self-assembled RNA “microsponges” and bubbled RNA cargos) are designed to transport and release therapeutic RNA with high efficiency and gene-silencing potency.
(2) Biosensing, where nucleic acids and aptamers are used to build rapid, hand-held-compatible platforms, including an RdRP-triggered RNA transcription assay that detects coronavirus signatures in ~30 minutes.
(3) Biomaterials, where free-standing RNA/DNA membranes and related macrostructures are fabricated and translated to devices such as tailor-made microneedles for transdermal delivery. Representative outputs include Nature Materials (RNA microsponges), Nano Letters (RdRP assay), and Materials Horizons (RNA-membrane microneedles).
Self-assembled RNA particles can modulate the cell fates.
DNA-inorganic hybrid superstructures can be grown into precisely controlled morphologies.
Enzyme-amplified nucleic acid can be fabricated into macroscopic platforms.
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