Publications
All Publications
2024
Seungyeon Han, Junhee Park, Sunghyun Moon, Seonghyeon Eom, Chang Min Jin, Seungmin Kim, Yong-Sang Ryu, Yeonho Choi, Jong Bum Lee and Inhee Choi
"Label-Free and Liquid State SERS Detection of Multi-Scaled Bioanalytes via Light-Induced Pinpoint Colloidal Assembly"
Biosensors and Bioelectronics. 264, 116663 (2024) IF=10.700 [Link]
Hyunji Kim*, Dajeong Kim*, Sunghyun Moon and Jong Bum Lee (*co-first authors)
"Efficient Circular RNA Synthesis through Gap-DNA Splint-Mediated Ligation"
Nanoscale. Advance Article (2024) [Link]
Yoonbin Ji, Taehyeon Kim, Dae Hoon Han and Jong Bum Lee
"Self-Healing And Thermal Responsive DNA Bioplastics for On-Demand Degradable Medical Devices"
ACS Materials Letters. 6, 4, 1277-1287 (2024) IF=11.400 [Link]
Sunghyun Moon and Jong Bum Lee
"Injectable Micro-Hydrogel for DNA Delivery: A Promising Therapeutic Platform"
Journal of Functional Biomaterials. 15(3), 59. (2024) [Link]
Dajeong Kim, So-Jung Kim, Jaepil Jeong, Sangwoo Han, Hyejin Kim, Seungki Lee, Inhee Choi, Jinkee Hong*, Jun-O Jin*, and Jong Bum Lee*
(*co-corresponding authors)
"Multimodal Golden DNA Superstructures (GDSs) for Highly Efficient Photothermal Immunotherapy"
ACS Nano. 18, 2, 1744–1755. (2024) IF=15.800 [Link]
2023
Hyangsu Nam, Taehyeon Kim, Sunghyun Moon, Yoonbin Ji, and Jong Bum Lee
"Self-Assembly of a Multimeric Genomic Hydrogel via Multi-Primed Chain Reaction of Dual Single-Stranded Circular Plasmids for Cell-Free Protein Production"
iScience. 26, 107089 (2023) [Link]
2022
Sangwoo Han, Dajeong Kim, Yoonbin Ji, Sunghyun Moon, and Jong Bum Lee
[Bookchapter] "Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications"
John Wiley & Sons. (2022) [Link]
Hyangsu Nam, Hyunsu Jeon, Hyejin Kim, Hong Yeol Yoon, Sun Hwa Kim, and Jong Bum Lee
"Module-Assembly of Injectable Cellular DNA Hydrogel via Clickable Cells And DNA Scaffolds"
Chemical Engineering Journal. 452, 139-492 (2022) IF=13.300 [Link]
Dajeong Kim*, Sangwoo Han*, Yoonbin Ji, Sunghyun Moon, Hyangsu Nam, and Jong Bum Lee (*co-first authors)
"Multimeric RNAs for Efficient RNA-Based Therapeutics And Vaccines"
Journal of Controlled Release. 345, 770-785 (2022) IF=10.500 [Link]
Dajeong Kim*, Sangwoo Han*, Yoonbin Ji, Heejeong Youn, Hyejin Kim, Ohsung Ko, Jong Bum Lee (*co-first authors)
"RNA Polymerization Actuating Nucleic Acid Membrane (RANAM)-Based Biosensing for Universal RNA Virus Detection"
Biosensors and Bioelectronics. 199, 113880 (2022) IF=10.700 [Link]
Yoonbin Ji, Dajeong Kim, Hyejin Kim, Sangwoo Han, Jong Bum Lee
"Construction of a Two-Dimensional DNA–RNA Hybridized Membrane for Collecting Tumor-Derived Exosomes"
Chemical Communications. 58, 266-269 (2022) [Link]
Hyunsu Jeon*, Yong Min Kim*, Sangwoo Han, Hong Chul Moon† and Jong Bum Lee† (*co-first authors, †co-corresponding authors)
"DNA Optoelectronics: Versatile Systems for On-Demand Functional Electrochemical Applications"
ACS Nano. 16(1), 241-250 (2022) IF=15.800 [Link]
2021
Yoonbin Ji, Jong Bum Lee
"DNA Microsponge-Templated Growth of Metal Nanoparticles for Signal-Enhanced Colorimetric Detection"
Applied Surface Science. 569, 151028 (2021) [Link]
Changho Chun*, Alec S.T. Smith*, Hyejin Kim, Dana S. Kamenza, Jung Hyun Lee, Jong Bum Lee, David L. Mack, Mark Bothwell, Claire D. Clelland, Deok-Ho Kim (*co-first authors)
"Astrocyte-derived Extracellular Vesicles Enhance the Survival and Electrophysiological Function of Human Cortical Neurons in vitro"
Biomaterials. 271, 120700 (2021) IF=12.800 [Link]
Sunghyun Moon, Hyejin Kim, Dajeong Kim, and Jong Bum Lee
"Viscosity-Regulated Control of RNA Microstructure Fabrication"
Polymers. 13(3), 454 (2021) [Link]
Sangwoo Han, Ohsung Ko, Geonhu Lee, Sun-Wook Jeong, Yong Jun Choi, and Jong Bum Lee
"Rapid Diagnosis of Coronavirus by RNA-Directed RNA Transcription Using an Engineered RNA-based Platform"
Nano Letters. 21(1), 462–468 (2021) [Link]
2020
Sangwoo Han, Yongkuk Park, Hyejin Kim, Hyangsu Nam, Ohsung Ko, Jong Bum Lee
"Double Controlled Release of Therapeutic RNA Modules Through Injectable DNA–RNA Hybrid Hydrogel"
ACS Applied Materials& Interfaces. 12(50), 55554-55563 (2020) [Link]
Dajeong Kim, Jieun Kim, Jong Bum Lee
"An Enzymatically Self-assembled DNA Patch for Enhanced Blood Coagulation"
Chemical Communications. 56, 5917-5920 (2020) [Link]
Hyounkoo Han, Doyeon Kim, Yongho Jang, Minkyu Seo, Kwangmeyung Kim, Jong Bum Lee, Hyuncheol Kim
"Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy"
Journal of Controlled Release. 322, 346-356 (2020) IF=10.500 [Link]
Ohsung Ko, Sangwoo Han, Jong Bum Lee
"Selective Release of DNA Nanostructures from DNA Hydrogel"
Journal of Industrial and Engineering Chemistry. 84, 46-51 (2020) [Link]
Hyejin Kim*, Yeon Kyung Lee*, Kyung Ho Han, Hyunsu Jeon, In-ho Jeong, Sang-Yeob Kim, Jong Bum Lee†, Peter C.W.Lee† (*co-first authors, †co-corresponding authors)
"BRC-mediated RNAi Targeting of USE1 Inhibits Tumor Growth in vitro and in vivo"
Biomaterials. 271, 120700 (2021) IF=12.800 [Link]
Dajeong Kim, Hyejin Kim, Peter Chang-Whan Lee* and Jong Bum Lee* (*co-corresponding authors)
"Universally Applicable RNA Membrane-based Microneedle System for Transdermal Drug Delivery"
Materials Horizons. 7, 1317-1326 (2020) IF=12.200 [Link]
2019
Hyunsu Jeon, Hyangsu Nam, and Jong Bum Lee
"Sustained Release of Minor-groove-binding Antibiotic Netropsin from Calcium-coated Groove-rich DNA Particles"
Pharmaceutics. 11, 387 (2019) [Link]
Hyangsu Nam, Sook Hee Ku, Hong Yeol Yoon, Kwangmeyung Kim, Ick Chan Kwon, Sun Hwa Kim*, and Jong Bum Lee* (*co-corresponding authors)
"Enhancing Systemic Delivery of Enzymatically Generated RNAi Nanocomplexes for Cancer Therapy"
Advanced Therapeutics. 2(6), 1900014 (2019) [Link]
Daheui Choi†, Hyejin Kim†, Dajeong Kim, Jiwoong Heo, Hwankyu Lee*, Jong Bum Lee*, and Jinkee Hong* (†co-first authors, *co-corresponding authors)
"Self-assembled DNA Hollow Spheres from Microsponges"
Biofabrication. 11, 025016 (2019) [Link]
Hyejin Kim, Dajeong Kim, Hyangsu Nam, Sunghyun Moon, Young Jik Kwon*, Jong Bum Lee* (*co-corresponding authors)
"Engineering Extracellular Vesicles and Their Mimetics for Clinical Translation"
Methods. 177, 80-94 (2019) [Link]
Dajeong Kim, Hyejin Kim, Sangwoo Han, Marta Scatena, Deok‐Ho Kim*, and Jong Bum Lee* (*co-corresponding authors)
"Immunostimulatory Effects Triggered by Self‐assembled Microspheres with Tandem Repeats of Polymerized RNA Strands"
Advanced Healthcare Materials. 8, 1801395 (2019) IF=10.000 [Link]
Hyunsu Jeon, Sangwoo Han, Hyejin Kim, Jong Bum Lee
"Surface Modification of RNA Nanoparticles by Ionic Interaction for Efficient Cellular Uptake"
Journal of Industrial and Engineering Chemistry. 70, 87-93 (2019) [Link]
2018
Hyejin Kim, Dajeong Kim, Jaepil Jeong, Hyunsu Jeon, and Jong Bum Lee
"Size-controllable Enzymatic Synthesis of Short Hairpin RNA Nanoparticles by Controlling the Rate of RNA Polymerization"
Polymers. 10(6), 589 (2018) [Link]
Sangwoo Han, Jong Bum Lee
"Self-assembly of Tumor-targeting RNA Nanoball for Carrier-free Delivery of Therapeutic RNA"
Journal of Industrial and Engineering Chemistry. 64, 90-96 (2018) [Link]
Heejung Jung†, Dajeong Kim†, Yoon Young Kang, Hyejin Kim, Jong Bum Lee*, and Hyejung Mok* (†co-first authors, *co-corresponding authors)
"CpG Incorporated DNA Microparticles for Elevated Immune Stimulation for Antigen Presenting Cells"
RSC Advances. 8, 6608-6615 (2018) [Link]
Hyejin Kim, Eunju Lee, Yoon Young Kang, Jihyun Song, Hyejung Mok*, and Jong Bum Lee* (*co-corresponding authors)
"Enzymatically Produced miR34a Nanoparticles for Enhanced Antiproliferation activity"
Advanced Biosystems. 2(2), 1700158 (2018) [Link]
2017
Jae Sung Lee†, Hyejin Kim†, Changshin Jo, Jaepil Jeong, Jeonghyun Ko, Sangwoo Han, Min Sun Lee, Ho-Young Lee, Jeong Woo Han, Jinwoo Lee, Jong Bum Lee (†co-first authors)
"Enzyme-driven Hasselback-like DNA-based Inorganic Superstructures"
Advanced Functional Materials. 27(45), 1704213 (2017) IF=18.500 [Link]
Na-kyung Ryoo, Jiwhang Lee, Hyunjoo Lee, Hye Kyoung Hong, Hyejin Kim, Jong Bum Lee, Se Joon Woo, Kyu Hyung Park, Hyuncheol Kim
"Therapeutic Effects of a Novel siRNA-based Anti-VEGF(siVEGF) Nanoball for the Treatment of Choroidal Neovascularization"
Nanoscale. 9, 15461-15469 (2017) [Link]
Sangwoo Han, Hyejin Kim, Jong Bum Lee
"Library siRNA-generating RNA Nanosponges for Gene Silencing by Complementary Rolling Circle Transcription"
Scientific Reports. 7, 10005 (2017) [Link]
Sangwoo Han, Jae Sung Lee, Jong Bum Lee
"Synthesis of Multi-functional DNA Nanosphere Barcode System for Direct Cell Detection"
Nanoscale. 9, 14094-14102 (2017) [Link]
Joseph Long, Hyejin Kim, Dajeong Kim, Jong Bum Lee*, Deok-Ho Kim* (*co-corresponding authors)
"A Biomaterials Approach to Cell Reprogramming and Differentiation"
Journal of Materials Chemistry B. 5, 2375-2389 (2017) [Link]
Hyejin Kim, Jaepil Jeong, Dajeong Kim, Gijung Kwak, Sun Hwa Kim*, Jong Bum Lee* (*co-corresponding authors)
"Bubbled RNA-based Cargo for Boosting RNA Interference"
Advanced Science. 4(8), 1600523 (2017) IF=14.300 [Link]
Jong Seong Ha†, Jaesung Lee†, Jaepil Jeong, Hyejin Kim, Juyoung Byun, Sang Ah Kim, Hee Jae Lee, Hak Suk Chung, Jong Bum Lee, Dae-Ro Ahn (†co-first authors)
"Poly-sgRNA/siRNA Ribonucleoprotein Nanoparticles for Targeted Gene Disruption"
Journal of Controlled Release. 250, 27-35 (2017) IF=10.500 [Link]
Jieun Kim, Dajeong Kim, Jong Bum Lee
"DNA Aptamer-based Carrier for Loading Proteins and Enhancing the Enzymatic Activity"
RSC Advances. 7, 1643-1645 (2017) [Link]
2016
Hyejin Kim, Jae Sung Lee, Jong Bum Lee
"Generation of siRNA Nanosheets for Efficient RNA Interference"
Scientific Reports. 6, 25146 (2016) [Link]
Jieun Kim, Jong Bum Lee
"Giant Catalytic DNA Particles for Simple and Intuitive Detection of Pb2+"
Nanoscale. 11, 244 (2016) [Link]
Jaepil Jeong, Hyejin Kim, Dong Jun Lee, Byung Jun Jung, Jong Bum Lee
"RCA-based Biosensor for Electrical and Colorimetric Detection of Pathogen DNA"
Nanoscale. 11, 242 (2016) [Link]
Yongkuk Park, Hyejin Kim, Jong Bum Lee
"Self-assembled DNA-guided RNA Nanovector via Step-wise Dual Enzyme Polymerization (SDEP) for Carrier-free siRNA Delivery"
ACS Biomaterials Science & Engineering. 2(4),616–624 (2016) [Link]
Hyejin Kim, Jong Bum Lee
"Formation of RNA Beads from Various DNA Nanoring Structures"
Journal of Nanoscience and Nanotechnology. 16(5), 4464-4468 (2016) [Link]
Hyejin Kim, Yongkuk Park, Jieun Kim, Jaepil Jeong, Sangwoo Han, Jae Sung Lee, Jong Bum Lee
"Nucleic Acid Engineering: RNA Following the Trail of DNA"
ACS Combinatorial Science. 18(2), 87-99 (2016) [Link]
Eun Hye Jeong, Hyejin Kim, Bora Jang, Hyesoo Cho, Jaehee Ryu, Boyeon Kim, Yonkuk Park, Jieun Kim, Jong Bum Lee*, Hyukjin Lee* (*co-corresponding authors)
"Technological Development of Structural DNA/RNA-based RNAi Systems and Their Applications"
Advanced Drug Delivery Reviews. 104, 29-43 (2015) IF=15.200 [Link]
Hyejin Kim, Yonkuk Park, Jong Bum Lee
"Self-assembled Messenger RNA Nanoparticles (mRNA-NPs) for Efficient Gene Expression"
Scientific Reports. 5, 12737 (2015) [Link]
2015
Jaepil Jeong, Hyejin Kim, Jong Bum Lee
"Enzymatic Polymerization on DNA Modified Gold Nanowire for Label-free Detection of Pathogen DNA"
International Journal of Molecular Sciences. 16(6), 13653-13660 (2015) [Link]
Jieun Kim, Jae Sung Lee, Jong Bum Lee
"Investigation of Förster Resonance Energy Transfer (FRET) and Competition of Fluorescent Dyes on DNA"
International Journal of Molecular Sciences. 16(4), 7738-7747 (2015) [Link]
2014
Hyangsu Nam, Hyejin Kim, Yonghun Park, Jong Hwan Sung, Bumsang Kim, Hyun Cheol Kim, Ju Woong Jang Jong Bum lee
"Fabrication of DNA-coated Microneedles for Transdermal DNA Delivery"
Science of Advanced Materials. 6(11), 2536-2539 (2014) [Link]
Young Hoon Roh†, Jong Bum Lee†, Kevin E. Shopsowitz, Erik C. Dreaden, Stephen W. Morton, Zhiyong Poon, Jinkee Hong, Inbar Yamin, Daniel K. Bonner, Paula T. Hammond (†co-first authors)
"Layer-by-Layer Assembled Antisense DNA Microsponge Particles for Efficient Delivery of Cancer Therapeutics"
ACS Nano. 8(10), 9767-9780 (2014) IF=15.800 [Link]
Daehoon Han, Yongkuk Park, Hyangsu Nam, Jong Bum Lee
"Enzymatic Size Control of RNA Particles Using Complementary Rolling Circle Transcription (cRCT) for Efficient siRNA Production"
Chemical Communications. 50, 11665-11667 (2014) [Link]
Daehoon Han, Yongkuk Park, Hyejin Kim, Jong Bum Lee
"Self-assembly of Free-standing RNA Membranes"
Nature Communications. 5, 4367 (2014) IF=14.700 [Link]
Younghyun Cho, Jong Bum Lee, Jinkee Hong
"Controlled Release of an Anti-cancer Drug from DNA Structured Nano-films"
Scientific Reports. 4, 4078 (2014) [Link]
2013
Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee
"Multiplexing Enhancement for the Detection of Multiple Pathogen DNA"
Journal of Nanoscience and Nanotechnology. 13(11), 7295-7299 (2013) [Link]
Jong Bum Lee, Jong Hwan Sung
"Organ-on-a-chip Technology and Microfluidic Whole-body Models for Pharmacokinetic Drug Toxicity Screening"
Biotechnology Journal. 8(11), 1258-1266 (2013) [Link]
Si Hyeon Kim, Jung Woo Lee, Inwook Choi, Young-Chan Kim, Jong Bum Lee, Jong Hwan Sung
"A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption"
Journal of Nanoscience and Nanotechnology. 13(11), 7220-7228 (2013) [Link]
Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee
"Aptamer-based Microspheres for Highly Sensitive Protein Detection Using Fluorescently-labeled DNA Nanostructures"
Journal of Nanoscience and Nanotechnology. 13(11), 7259-7263 (2013) [Link]
Jong Bum Lee, Kim Hyuncheol
"Control of Nanoparticles on Branched DNA Nanostructures"
Journal of Biomedical Nanotechnology. 9(7), 1245-1249 (2013) [Link]
Jong Bum Lee, Kim Hyuncheol
"Stability of DNA Nanostructures by Junction Penalty"
Journal of Biomedical Nanotechnology. 9(4), 644-648 (2013) [Link]
Younghyun Cho, Jong Bum Lee, Jinkee Hong
"Tunable Growth Factor Release from Nano-assembled Starch Multilayers"
Chemical Engineering Journal. 221, 32-36 (2013) IF=13.300 [Link]
Jong Hwan Sung, Daehoon Han, Jong Bum Lee
"Self-assembled DNA-based Giant Thrombin Nanoparticles for Controlled Release"
Biotechnology Journal. 8(2), 215-220 (2013) [Link]
2012
Jong Bum Lee, Songming Peng, Dayong Yang, Young Hoon Roh, Hisakage Funabashi, Nokyoung Park, Edward J. Rice, Liwei Chen, Rong Long, Mingming Wu, Dan Luo
"A Mechanical Metamaterial Made from a DNA Hydrogel"
Daehoon Han, Jong Bum Lee
"핵산 나노기술 (Nucleic Acid Nanotechnology)의 의학적 응용"
Jong Bum Lee, Jinkee Hong, Daniel K. Bonner, Zhiyong Poon, Paula T. Hammond
"Self-assembled RNA Interference Microsponges for Efficient siRNA Delivery"
Subhasish Chatterjee, Jong Bum Lee, Nikesh V. Valappil, Dan Luo, Vinod M. Menon
"Probing Y-shaped DNA Structure with Time-resolved FRET"
Previous Study (~2011)
Jinkee Hong, Nisarg J. Shah, Adam C. Drake, Peter C. DeMuth, Jong Bum Lee, Jianzhu Chen, Paula T. Hammond
"Graphene Multilayers as Gates for Multi-week Sequential Release of Proteins from Surfaces"
Young Hoon Roh, Roanna C. H. Ruiz, Songming Peng, Jong Bum Lee, Dan Luo
"Engineering DNA-based Functional Materials"
Zhiyong Poon, Jong Bum Lee, Stephen W. Morton, Paula T. Hammond
"Controlling in vivo Stability and Biodistribution in Electrostatically Assembled Nanoparticles for Systemic Delivery"
Young Hoon Roh, Jong Bum Lee, Pichamon Kiatwuthinon, Mark R. Hartman, Judy J. Cha, Soong Ho Um, David A. Muller, Dan Luo
"DNAsomes: Multifunctional DNA-based Nanocarriers"
Jong Bum Lee, Adam S. Shai, Michael J. Campolongo, Nokyoung Park, Dan Luo
"Three-dimentional Structure and Thermal Stability Studies of DNA Nanostructures by Energy Transfer Spectroscopy"
Young Hoon Roh, Jong Bum Lee, Shawn J. Tan, Bojeong Kim, Hyeongsu Park, Edward J. Rice, Dan Luo
"Photocrosslinked DNA Nanospheres for Drug Delivery"
Jong Bum Lee, Michael John Campolongo, Jason Samuel Kahn, Young Hoon Roh, Mark Richard Hartman, Dan Luo
"DNA-based Nanostructures for Molecular Sensing"
Jong Bum Lee, Young H. Roh, Soong Ho Um, Hisakage Funabashi, Wenlong Cheng, Judy J. Cha, Pichamon Kiatwuthinon, David A. Muller, Dan Luo
"Multifunctional Nanoarchitectures from DNA-based ABC Monomers"
Dwaipayan Sil, Jong Bum Lee, Dan Luo, David Holowka, Barbara Baird
"Trivalent Ligands with Rigid DNA Spacers Reveal Structural Requirements for IgE Recepter Signaling in RBL Mast Cells"
Soong Ho Um, Jong Bum Lee, Nokyoung Park, Sang Yeon Kwon, Christopher C. Umbach, Dan Luo
"Enzyme-catalysed Assembly of DNA Hydrogel"
Soong Ho Um, Jong Bum Lee, Sang Yeon Kwon, Yougen Li, Dan Luo
"Dendrimer-like DNA-based Fluorescence Nanobarcodes"