All Publications
2025
Kanchan Yadav, Iksoo Jang and Jong Bum Lee
"Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations"
Advanced Engineering Materials. Advance article (2025) [Link]
Iksoo Jang*, Kyuha Yum*, Sangwoo Han*, Sunghyun Moon and Jong Bum Lee (*co-first authors)
"A virus-inspired RNA mimicry approach for effective cancer immunotherapy"
Journal of Materials Chemistry B. Advance article (2025) [Link]
2024
Seungyeon Han, Junhee Park, Sunghyun Moon, Seonghyeon Eom, Chang Min Jin, Seungmin Kim, Yong-Sang Ryu, Yeonho Choi, Jong Bum Lee and Inhee Choi
"Label-Free and Liquid State SERS Detection of Multi-Scaled Bioanalytes via Light-Induced Pinpoint Colloidal Assembly"
Biosensors and Bioelectronics. 264, 116663 (2024) IF=10.700 [Link]
Hyunji Kim*, Dajeong Kim*, Sunghyun Moon and Jong Bum Lee (*co-first authors)
"Efficient Circular RNA Synthesis through Gap-DNA Splint-Mediated Ligation"
Nanoscale. Advance Article (2024) [Link]
Yoonbin Ji, Taehyeon Kim, Dae Hoon Han and Jong Bum Lee
"Self-Healing And Thermal Responsive DNA Bioplastics for On-Demand Degradable Medical Devices"
ACS Materials Letters. 6, 4, 1277-1287 (2024) IF=11.400 [Link]
Sunghyun Moon and Jong Bum Lee
"Injectable Micro-Hydrogel for DNA Delivery: A Promising Therapeutic Platform"
Journal of Functional Biomaterials. 15(3), 59. (2024) [Link]
Dajeong Kim, So-Jung Kim, Jaepil Jeong, Sangwoo Han, Hyejin Kim, Seungki Lee, Inhee Choi, Jinkee Hong*, Jun-O Jin*, and Jong Bum Lee*
(*co-corresponding authors)
"Multimodal Golden DNA Superstructures (GDSs) for Highly Efficient Photothermal Immunotherapy"
ACS Nano. 18, 2, 1744–1755. (2024) IF=15.800 [Link]
2023
Hyangsu Nam, Taehyeon Kim, Sunghyun Moon, Yoonbin Ji, and Jong Bum Lee
"Self-Assembly of a Multimeric Genomic Hydrogel via Multi-Primed Chain Reaction of Dual Single-Stranded Circular Plasmids for Cell-Free Protein Production"
iScience. 26, 107089 (2023) [Link]
2022
Sangwoo Han, Dajeong Kim, Yoonbin Ji, Sunghyun Moon, and Jong Bum Lee
[Bookchapter] "Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications"
John Wiley & Sons. (2022) [Link]
Hyangsu Nam, Hyunsu Jeon, Hyejin Kim, Hong Yeol Yoon, Sun Hwa Kim, and Jong Bum Lee
"Module-Assembly of Injectable Cellular DNA Hydrogel via Clickable Cells And DNA Scaffolds"
Chemical Engineering Journal. 452, 139-492 (2022) IF=13.300 [Link]
Dajeong Kim*, Sangwoo Han*, Yoonbin Ji, Sunghyun Moon, Hyangsu Nam, and Jong Bum Lee (*co-first authors)
"Multimeric RNAs for Efficient RNA-Based Therapeutics And Vaccines"
Journal of Controlled Release. 345, 770-785 (2022) IF=10.500 [Link]
Dajeong Kim*, Sangwoo Han*, Yoonbin Ji, Heejeong Youn, Hyejin Kim, Ohsung Ko, Jong Bum Lee (*co-first authors)
"RNA Polymerization Actuating Nucleic Acid Membrane (RANAM)-Based Biosensing for Universal RNA Virus Detection"
Biosensors and Bioelectronics. 199, 113880 (2022) IF=10.700 [Link]
Yoonbin Ji, Dajeong Kim, Hyejin Kim, Sangwoo Han, Jong Bum Lee
"Construction of a Two-Dimensional DNA–RNA Hybridized Membrane for Collecting Tumor-Derived Exosomes"
Chemical Communications. 58, 266-269 (2022) [Link]
Hyunsu Jeon*, Yong Min Kim*, Sangwoo Han, Hong Chul Moon† and Jong Bum Lee† (*co-first authors, †co-corresponding authors)
"DNA Optoelectronics: Versatile Systems for On-Demand Functional Electrochemical Applications"
ACS Nano. 16(1), 241-250 (2022) IF=15.800 [Link]
2021
Yoonbin Ji, Jong Bum Lee
"DNA Microsponge-Templated Growth of Metal Nanoparticles for Signal-Enhanced Colorimetric Detection"
Applied Surface Science. 569, 151028 (2021) [Link]
Changho Chun*, Alec S.T. Smith*, Hyejin Kim, Dana S. Kamenza, Jung Hyun Lee, Jong Bum Lee, David L. Mack, Mark Bothwell, Claire D. Clelland, Deok-Ho Kim (*co-first authors)
"Astrocyte-derived Extracellular Vesicles Enhance the Survival and Electrophysiological Function of Human Cortical Neurons in vitro"
Biomaterials. 271, 120700 (2021) IF=12.800 [Link]
Sunghyun Moon, Hyejin Kim, Dajeong Kim, and Jong Bum Lee
"Viscosity-Regulated Control of RNA Microstructure Fabrication"
Polymers. 13(3), 454 (2021) [Link]
Sangwoo Han, Ohsung Ko, Geonhu Lee, Sun-Wook Jeong, Yong Jun Choi, and Jong Bum Lee
"Rapid Diagnosis of Coronavirus by RNA-Directed RNA Transcription Using an Engineered RNA-based Platform"
Nano Letters. 21(1), 462–468 (2021) [Link]
2020
Sangwoo Han, Yongkuk Park, Hyejin Kim, Hyangsu Nam, Ohsung Ko, Jong Bum Lee
"Double Controlled Release of Therapeutic RNA Modules Through Injectable DNA–RNA Hybrid Hydrogel"
ACS Applied Materials& Interfaces. 12(50), 55554-55563 (2020) [Link]
Dajeong Kim, Jieun Kim, Jong Bum Lee
"An Enzymatically Self-assembled DNA Patch for Enhanced Blood Coagulation"
Chemical Communications. 56, 5917-5920 (2020) [Link]
Hyounkoo Han, Doyeon Kim, Yongho Jang, Minkyu Seo, Kwangmeyung Kim, Jong Bum Lee, Hyuncheol Kim
"Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy"
Journal of Controlled Release. 322, 346-356 (2020) IF=10.500 [Link]
Ohsung Ko, Sangwoo Han, Jong Bum Lee
"Selective Release of DNA Nanostructures from DNA Hydrogel"
Journal of Industrial and Engineering Chemistry. 84, 46-51 (2020) [Link]
Hyejin Kim*, Yeon Kyung Lee*, Kyung Ho Han, Hyunsu Jeon, In-ho Jeong, Sang-Yeob Kim, Jong Bum Lee†, Peter C.W.Lee† (*co-first authors, †co-corresponding authors)
"BRC-mediated RNAi Targeting of USE1 Inhibits Tumor Growth in vitro and in vivo"
Biomaterials. 271, 120700 (2021) IF=12.800 [Link]
Dajeong Kim, Hyejin Kim, Peter Chang-Whan Lee* and Jong Bum Lee* (*co-corresponding authors)
"Universally Applicable RNA Membrane-based Microneedle System for Transdermal Drug Delivery"
Materials Horizons. 7, 1317-1326 (2020) IF=12.200 [Link]
2019
Hyunsu Jeon, Hyangsu Nam, and Jong Bum Lee
"Sustained Release of Minor-groove-binding Antibiotic Netropsin from Calcium-coated Groove-rich DNA Particles"
Pharmaceutics. 11, 387 (2019) [Link]
Hyangsu Nam, Sook Hee Ku, Hong Yeol Yoon, Kwangmeyung Kim, Ick Chan Kwon, Sun Hwa Kim*, and Jong Bum Lee* (*co-corresponding authors)
"Enhancing Systemic Delivery of Enzymatically Generated RNAi Nanocomplexes for Cancer Therapy"
Advanced Therapeutics. 2(6), 1900014 (2019) [Link]
Daheui Choi†, Hyejin Kim†, Dajeong Kim, Jiwoong Heo, Hwankyu Lee*, Jong Bum Lee*, and Jinkee Hong* (†co-first authors, *co-corresponding authors)
"Self-assembled DNA Hollow Spheres from Microsponges"
Biofabrication. 11, 025016 (2019) [Link]
Hyejin Kim, Dajeong Kim, Hyangsu Nam, Sunghyun Moon, Young Jik Kwon*, Jong Bum Lee* (*co-corresponding authors)
"Engineering Extracellular Vesicles and Their Mimetics for Clinical Translation"
Methods. 177, 80-94 (2019) [Link]
Dajeong Kim, Hyejin Kim, Sangwoo Han, Marta Scatena, Deok‐Ho Kim*, and Jong Bum Lee* (*co-corresponding authors)
"Immunostimulatory Effects Triggered by Self‐assembled Microspheres with Tandem Repeats of Polymerized RNA Strands"
Advanced Healthcare Materials. 8, 1801395 (2019) IF=10.000 [Link]
Hyunsu Jeon, Sangwoo Han, Hyejin Kim, Jong Bum Lee
"Surface Modification of RNA Nanoparticles by Ionic Interaction for Efficient Cellular Uptake"
Journal of Industrial and Engineering Chemistry. 70, 87-93 (2019) [Link]
2018
Hyejin Kim, Dajeong Kim, Jaepil Jeong, Hyunsu Jeon, and Jong Bum Lee
"Size-controllable Enzymatic Synthesis of Short Hairpin RNA Nanoparticles by Controlling the Rate of RNA Polymerization"
Polymers. 10(6), 589 (2018) [Link]
Sangwoo Han, Jong Bum Lee
"Self-assembly of Tumor-targeting RNA Nanoball for Carrier-free Delivery of Therapeutic RNA"
Journal of Industrial and Engineering Chemistry. 64, 90-96 (2018) [Link]
Heejung Jung†, Dajeong Kim†, Yoon Young Kang, Hyejin Kim, Jong Bum Lee*, and Hyejung Mok* (†co-first authors, *co-corresponding authors)
"CpG Incorporated DNA Microparticles for Elevated Immune Stimulation for Antigen Presenting Cells"
RSC Advances. 8, 6608-6615 (2018) [Link]
Hyejin Kim, Eunju Lee, Yoon Young Kang, Jihyun Song, Hyejung Mok*, and Jong Bum Lee* (*co-corresponding authors)
"Enzymatically Produced miR34a Nanoparticles for Enhanced Antiproliferation activity"
Advanced Biosystems. 2(2), 1700158 (2018) [Link]
2017
Jae Sung Lee†, Hyejin Kim†, Changshin Jo, Jaepil Jeong, Jeonghyun Ko, Sangwoo Han, Min Sun Lee, Ho-Young Lee, Jeong Woo Han, Jinwoo Lee, Jong Bum Lee (†co-first authors)
"Enzyme-driven Hasselback-like DNA-based Inorganic Superstructures"
Advanced Functional Materials. 27(45), 1704213 (2017) IF=18.500 [Link]
Na-kyung Ryoo, Jiwhang Lee, Hyunjoo Lee, Hye Kyoung Hong, Hyejin Kim, Jong Bum Lee, Se Joon Woo, Kyu Hyung Park, Hyuncheol Kim
"Therapeutic Effects of a Novel siRNA-based Anti-VEGF(siVEGF) Nanoball for the Treatment of Choroidal Neovascularization"
Nanoscale. 9, 15461-15469 (2017) [Link]
Sangwoo Han, Hyejin Kim, Jong Bum Lee
"Library siRNA-generating RNA Nanosponges for Gene Silencing by Complementary Rolling Circle Transcription"
Scientific Reports. 7, 10005 (2017) [Link]
Sangwoo Han, Jae Sung Lee, Jong Bum Lee
"Synthesis of Multi-functional DNA Nanosphere Barcode System for Direct Cell Detection"
Nanoscale. 9, 14094-14102 (2017) [Link]
Joseph Long, Hyejin Kim, Dajeong Kim, Jong Bum Lee*, Deok-Ho Kim* (*co-corresponding authors)
"A Biomaterials Approach to Cell Reprogramming and Differentiation"
Journal of Materials Chemistry B. 5, 2375-2389 (2017) [Link]
Hyejin Kim, Jaepil Jeong, Dajeong Kim, Gijung Kwak, Sun Hwa Kim*, Jong Bum Lee* (*co-corresponding authors)
"Bubbled RNA-based Cargo for Boosting RNA Interference"
Advanced Science. 4(8), 1600523 (2017) IF=14.300 [Link]
Jong Seong Ha†, Jaesung Lee†, Jaepil Jeong, Hyejin Kim, Juyoung Byun, Sang Ah Kim, Hee Jae Lee, Hak Suk Chung, Jong Bum Lee, Dae-Ro Ahn (†co-first authors)
"Poly-sgRNA/siRNA Ribonucleoprotein Nanoparticles for Targeted Gene Disruption"
Journal of Controlled Release. 250, 27-35 (2017) IF=10.500 [Link]
Jieun Kim, Dajeong Kim, Jong Bum Lee
"DNA Aptamer-based Carrier for Loading Proteins and Enhancing the Enzymatic Activity"
RSC Advances. 7, 1643-1645 (2017) [Link]
2016
Hyejin Kim, Jae Sung Lee, Jong Bum Lee
"Generation of siRNA Nanosheets for Efficient RNA Interference"
Scientific Reports. 6, 25146 (2016) [Link]
Jieun Kim, Jong Bum Lee
"Giant Catalytic DNA Particles for Simple and Intuitive Detection of Pb2+"
Nanoscale. 11, 244 (2016) [Link]
Jaepil Jeong, Hyejin Kim, Dong Jun Lee, Byung Jun Jung, Jong Bum Lee
"RCA-based Biosensor for Electrical and Colorimetric Detection of Pathogen DNA"
Nanoscale. 11, 242 (2016) [Link]
Yongkuk Park, Hyejin Kim, Jong Bum Lee
"Self-assembled DNA-guided RNA Nanovector via Step-wise Dual Enzyme Polymerization (SDEP) for Carrier-free siRNA Delivery"
ACS Biomaterials Science & Engineering. 2(4),616–624 (2016) [Link]
Hyejin Kim, Jong Bum Lee
"Formation of RNA Beads from Various DNA Nanoring Structures"
Journal of Nanoscience and Nanotechnology. 16(5), 4464-4468 (2016) [Link]
Hyejin Kim, Yongkuk Park, Jieun Kim, Jaepil Jeong, Sangwoo Han, Jae Sung Lee, Jong Bum Lee
"Nucleic Acid Engineering: RNA Following the Trail of DNA"
ACS Combinatorial Science. 18(2), 87-99 (2016) [Link]
Eun Hye Jeong, Hyejin Kim, Bora Jang, Hyesoo Cho, Jaehee Ryu, Boyeon Kim, Yonkuk Park, Jieun Kim, Jong Bum Lee*, Hyukjin Lee* (*co-corresponding authors)
"Technological Development of Structural DNA/RNA-based RNAi Systems and Their Applications"
Advanced Drug Delivery Reviews. 104, 29-43 (2015) IF=15.200 [Link]
Hyejin Kim, Yonkuk Park, Jong Bum Lee
"Self-assembled Messenger RNA Nanoparticles (mRNA-NPs) for Efficient Gene Expression"
Scientific Reports. 5, 12737 (2015) [Link]
2015
Jaepil Jeong, Hyejin Kim, Jong Bum Lee
"Enzymatic Polymerization on DNA Modified Gold Nanowire for Label-free Detection of Pathogen DNA"
International Journal of Molecular Sciences. 16(6), 13653-13660 (2015) [Link]
Jieun Kim, Jae Sung Lee, Jong Bum Lee
"Investigation of Förster Resonance Energy Transfer (FRET) and Competition of Fluorescent Dyes on DNA"
International Journal of Molecular Sciences. 16(4), 7738-7747 (2015) [Link]
2014
Hyangsu Nam, Hyejin Kim, Yonghun Park, Jong Hwan Sung, Bumsang Kim, Hyun Cheol Kim, Ju Woong Jang Jong Bum lee
"Fabrication of DNA-coated Microneedles for Transdermal DNA Delivery"
Science of Advanced Materials. 6(11), 2536-2539 (2014) [Link]
Young Hoon Roh†, Jong Bum Lee†, Kevin E. Shopsowitz, Erik C. Dreaden, Stephen W. Morton, Zhiyong Poon, Jinkee Hong, Inbar Yamin, Daniel K. Bonner, Paula T. Hammond (†co-first authors)
"Layer-by-Layer Assembled Antisense DNA Microsponge Particles for Efficient Delivery of Cancer Therapeutics"
ACS Nano. 8(10), 9767-9780 (2014) IF=15.800 [Link]
Daehoon Han, Yongkuk Park, Hyangsu Nam, Jong Bum Lee
"Enzymatic Size Control of RNA Particles Using Complementary Rolling Circle Transcription (cRCT) for Efficient siRNA Production"
Chemical Communications. 50, 11665-11667 (2014) [Link]
Daehoon Han, Yongkuk Park, Hyejin Kim, Jong Bum Lee
"Self-assembly of Free-standing RNA Membranes"
Nature Communications. 5, 4367 (2014) IF=14.700 [Link]
Younghyun Cho, Jong Bum Lee, Jinkee Hong
"Controlled Release of an Anti-cancer Drug from DNA Structured Nano-films"
Scientific Reports. 4, 4078 (2014) [Link]
2013
Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee
"Multiplexing Enhancement for the Detection of Multiple Pathogen DNA"
Journal of Nanoscience and Nanotechnology. 13(11), 7295-7299 (2013) [Link]
Jong Bum Lee, Jong Hwan Sung
"Organ-on-a-chip Technology and Microfluidic Whole-body Models for Pharmacokinetic Drug Toxicity Screening"
Biotechnology Journal. 8(11), 1258-1266 (2013) [Link]
Si Hyeon Kim, Jung Woo Lee, Inwook Choi, Young-Chan Kim, Jong Bum Lee, Jong Hwan Sung
"A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption"
Journal of Nanoscience and Nanotechnology. 13(11), 7220-7228 (2013) [Link]
Daehoon Han, Jinkee Hong, Hyun Cheol Kim, Jong Hwan Sung, Jong Bum Lee
"Aptamer-based Microspheres for Highly Sensitive Protein Detection Using Fluorescently-labeled DNA Nanostructures"
Journal of Nanoscience and Nanotechnology. 13(11), 7259-7263 (2013) [Link]
Jong Bum Lee, Kim Hyuncheol
"Control of Nanoparticles on Branched DNA Nanostructures"
Journal of Biomedical Nanotechnology. 9(7), 1245-1249 (2013) [Link]
Jong Bum Lee, Kim Hyuncheol
"Stability of DNA Nanostructures by Junction Penalty"
Journal of Biomedical Nanotechnology. 9(4), 644-648 (2013) [Link]
Younghyun Cho, Jong Bum Lee, Jinkee Hong
"Tunable Growth Factor Release from Nano-assembled Starch Multilayers"
Chemical Engineering Journal. 221, 32-36 (2013) IF=13.300 [Link]
Jong Hwan Sung, Daehoon Han, Jong Bum Lee
"Self-assembled DNA-based Giant Thrombin Nanoparticles for Controlled Release"
Biotechnology Journal. 8(2), 215-220 (2013) [Link]
2012
"A Mechanical Metamaterial Made from a DNA Hydrogel"
"핵산 나노기술 (Nucleic Acid Nanotechnology)의 의학적 응용"
"Self-assembled RNA Interference Microsponges for Efficient siRNA Delivery"
"Probing Y-shaped DNA Structure with Time-resolved FRET"
Previous Study (~2011)
"Graphene Multilayers as Gates for Multi-week Sequential Release of Proteins from Surfaces"
"Engineering DNA-based Functional Materials"
"Controlling in vivo Stability and Biodistribution in Electrostatically Assembled Nanoparticles for Systemic Delivery"
"DNAsomes: Multifunctional DNA-based Nanocarriers"
"Three-dimentional Structure and Thermal Stability Studies of DNA Nanostructures by Energy Transfer Spectroscopy"
"Photocrosslinked DNA Nanospheres for Drug Delivery"
"DNA-based Nanostructures for Molecular Sensing"
"Multifunctional Nanoarchitectures from DNA-based ABC Monomers"
"Trivalent Ligands with Rigid DNA Spacers Reveal Structural Requirements for IgE Recepter Signaling in RBL Mast Cells"
"Enzyme-catalysed Assembly of DNA Hydrogel"
"Dendrimer-like DNA-based Fluorescence Nanobarcodes"